- Muscarinic receptors control markers of inflammation in the small intestine of BALB/c mice.
Muscarinic receptors control markers of inflammation in the small intestine of BALB/c mice.
Journal of neuroimmunology (2021-11-26)
Ivonne Maciel Arciniega-Martínez, Judith Pacheco-Yépez, Mónica Miguel Santamaria-Chávez, Xóchitl Abril Rebollar-Ruíz, Luz María Cárdenas-Jaramillo, Rosa Adriana Jarillo-Luna, Rafael Campos-Rodríguez, Maria Elisa Drago-Serrano, Aldo Arturo Reséndiz-Albor
PMID34823118
RESUMEN
Muscarinic-acetylcholine-receptors (mAChRs) modulate intestinal homeostasis, but their role in inflammation is unclear; thus, this issue was the focus of this study. BALB/c mice were treated for 7 days with muscarine (mAChR/agonist), atropine (mAChR/antagonist) or saline. Small-intestine samples were collected for histology and cytofluorometric assays in Peyer's patches (PP) and lamina propria (LP) cell-suspensions. In LP, goblet-cells/leukocytes/neutrophils/MPO+ cells and MPO/activity were increased in the muscarine group. In PP, IFN-γ+/CD4+ T or IL-6+/CD4+ T cell numbers were higher in the muscarine or atropine groups, respectively. In LP, TNF-α+/CD4+ T cell number was higher in the muscarine group and lower in the atropine.
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