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Affinity Chromatography Resins

Affinity chromatography separates complex mixtures through highly selective biochemical interactions. This widely used purification technology efficiently separates a target molecule from impurities. Our range of affinity resins are designed for high throughput and cost-effective purification, from process development through large-scale manufacturing.

Protein A Affinity Resins

  • Eshmuno® A is a high-capacity resin for the purification of Fc-containing proteins, such as monoclonal antibodies (mAbs). This resin can be sanitized under acid and alkaline conditions.

Affinity Resins for Plasma Purification

Eshmuno® P anti-A and anti-B resins effectively remove anti-A and anti-B isoagglutinin antibodies in plasma-derived Immunoglobulin (Ig) processes, which has been associated with increased patient risk for hemolysis.

 

Affinity Resins for Protein Purification

Fractogel® Metal Chelate resin offers efficient and cost-effective separation of proteins and peptides, especially proteins with exposed histidine, cysteine, and tryptophan residues, including histidine-tagged proteins.

Support for qualification, risk assessment, and process optimization

Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

RELATED PRODUCT RESOURCES

mAb Expression, Purification, and Formulation

mAbsizer™ Calculator

Product Selection

Biochromatography Portfolio Guide
Chromatography Purification Selection Guide

Product Specifications

Data Sheet: Eshmuno® A Resin
Data Sheet: Eshmuno® P anti-A and anti-B Resins
Data Sheet: Fractogel® Chromatography Resin
Application Note: Using Ethylene Glycol Emprove® Evolve to increase Eshmuno® A chromatography resin lifetime

Product Operations

Application Note: Detection and Quantification of Leached Protein A from Eshmuno® A Resin Using Cygnus F400 Protein A ELISA Kit
User Guide: MiniChrom® Pre-Packed Columns

 

Related Product Categories
Chromatography Columns for Bioprocessing
Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale. From screening to large-scale production, our columns provide robust and consistent performance with the processing flexibility you need.
Chromatography Systems for Bioprocessing
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.
Membrane Chromatography
Optimize downstream purification using membrane chromatography for capture and polishing. Natrix membranes boost economics and facility efficiency.
Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography separates biomolecules based on the difference in charge between the target molecule and chromatography resin.
Reverse Phase/Normal Phase Chromatography Resins
Enhance biomolecule separation: HPLC silica gel resins deliver high purity, exceptional separation. Explore our broad, cost-effective portfolio.
Buffers & pH Adjusters
Our broad portfolio of buffer materials manufactured according to GMP guidelines includes excipients specifically for drug formulation and manufacturing, including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters with regulatory support.
Size Exclusion Chromatography Resins
Size exclusion chromatography (SEC) is a purification method used for separating substances based on their molecular size. Widely used in commercial bioseparation processes, size exclusion chromatography is a versatile technique because buffer composition does not impact separation effectiveness.
RELATED APPLICATIONS
Blood Plasma Fractionation
Consistent, reliable performance is key to blood plasma fractionation, posing challenges to improve yield, maintain process economics, and manage regulatory requirements. Learn how the right partner can help fractionators to better serve patients globally with enhanced IgG, albumin, and Factor VIII products.
Monoclonal Antibody Manufacturing
Monoclonal antibody manufacturing is a highly templated approach used to produce mAb-based immunotherapies. Robust, scalable process solutions are required at every step to ensure high therapeutic concentration and process safety, while meeting speed-to-market and cost containment concerns.
Pharma & Biopharma Startup Hub
Your new molecule or therapy begins its journey here. Find solutions and resources to navigate your path to successful drug discovery, development, and commercialization.
RELATED SERVICES
Emprove® Chromatography
The Emprove® Chromatography portfolio streamlines resin selection and qualification for biopharmaceutical manufacturers, built to address process-specific needs at steps from early to late downstream.

Highlights

Webinar: Addressing Immunoglobulin (Ig) Purification Challenges with Chromatographic Technologies
Webinar: Addressing Immunoglobulin (Ig) Purification Challenges with Chromatographic Technologies

Strategies to address Immunoglobulin purification challenges by using Ion Exchange and Affinity chromatography media to enhance both purity & yield.

Webinar: Protein A Affinity Chromatography: How to Capitalize on its Purification Potential
Webinar: Protein A Affinity Chromatography: How to Capitalize on its Purification Potential

Learn productivity & COGs calculations of Protein A affinity chromatography resin at production scale, including best practice strategies to lower costs.

Webinar: Extractables Profiles for Chromatography Resins – Adapted Approach of Upcoming USP
Webinar: Extractables Profiles for Chromatography Resins – Adapted Approach of Upcoming USP

This webinar will cover our study design for extractables profiles of chromatography resins within our Emprove® Program.

Chromatography Supply Program
Chromatography Supply Program

Chromatography Supply Program As a leading partner and supplier to the biopharmaceutical industry, we continue to strengthen our supply chain to help you stay ahead.

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