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SML0594

Sigma-Aldrich

CGP 55845 hydrochloride

≥98% (HPLC)

Sinónimos:

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydro xypropyl](phenylmethyl)phosphinic acid hydrochloride, CGP 55845A, CGP55845

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About This Item

Fórmula empírica (notación de Hill):
C18H22Cl2NO3P · HCl
Número de CAS:
149184-22-5
Peso molecular:
438.71
Código UNSPSC:
12352200
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

room temp

InChI

1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

Clave InChI

ZODSPDOOCZZEIM-BBRMVZONSA-N

Acciones bioquímicas o fisiológicas

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Dustin Anderson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7811-7824 (2013-05-03)
Synaptic transmission and neuronal excitability depend on the concentration of extracellular calcium ([Ca](o)), yet repetitive synaptic input is known to decrease [Ca](o) in numerous brain regions. In the cerebellar molecular layer, synaptic input reduces [Ca](o) by up to 0.4 mm
Volodymyr Dzhala et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(12), 4017-4031 (2012-03-24)
Severe head trauma causes widespread neuronal shear injuries and acute seizures. Shearing of neural processes might contribute to seizures by disrupting the transmembrane ion gradients that subserve normal synaptic signaling. To test this possibility, we investigated changes in intracellular chloride
Wendy W Wu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(7), 2638-2648 (2011-02-18)
Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are prevented with estrogen (E(2))-containing hormone replacement therapy initiated shortly following OVX but not after substantial delay. Currently, the cellular
Court A Hull et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 5895-5902 (2013-04-05)
Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics
Michael H Myoga et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(14), 5235-5243 (2011-04-08)
R-type calcium channels in postsynaptic spines signal through functional calcium microdomains to regulate a calcium/calmodulin-sensitive potassium channel that in turn regulates postsynaptic hippocampal long-term potentiation (LTP). Here, we ask whether R-type calcium channels in presynaptic terminals also signal through calcium
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