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Key Documents

SAB2900695

Sigma-Aldrich

Anti-ADCYAP1R1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

ADCYAP1R1, PAC1, PAC1-R, PACAP receptor 1, Pac1 receptor, Pac1 receptors

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

reactividad de especies

dog, human, Xenopus, chicken, monkey

técnicas

immunohistochemistry: 15 μg/mL

Nº de acceso UniProt

P41586

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ADCYAP1R1(117)

Descripción general

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein is a member of the class B G-protein-coupled receptors (GPCRs). It is expressed ubiquitously in the central nervous system (CNS) and peripheral tissues. It has an N-terminal extracellular domain (ECD) and a transmembrane domain (TMD). ADCYAP1R1 gene is located on human chromosome 7p14.

Inmunógeno

Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Bat, Chicken, Lizard, Xenopus (100%); Stickleback, Pufferfish, Zebrafish (94%); Mouse, Rat, Hamster, Elephant, Bovine, Horse, Pig (88%).

Acciones bioquímicas o fisiológicas

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein can activate the adenylyl cyclase stimulatory G protein Gs. It regulates circadian rhythm, food intake, and the immune system. PAC1R plays a vital role in glucose metabolism, learning and memory, neuronal ontogenesis, and apoptosis. ADCYAP1R1 is identified as a potential drug target for mental disorders and dry eye syndrome.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Supplied at 1 mg/ml

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kazuhiro Kobayashi et al.
Nature structural & molecular biology, 27(3), 274-280 (2020-03-12)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide hormone. The PACAP receptor PAC1R, which belongs to the class B G-protein-coupled receptors (GPCRs), is a drug target for mental disorders and dry eye syndrome. Here, we present a cryo-EM structure
Motokazu Koga et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(4), 383-391 (2014-06-21)
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating peptide (PACAP) have pulmonary vasodilatory and positive inotropic effects via receptors VPAC1 and VPAC2, which possess a similar affinity for both

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