SAB1306388

ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: ACVR1, ACVRLK2, Activin receptor type I, Activin receptor type-1, Activin receptor-like kinase 2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: 57153 Da
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: 1:50-1:100; western blot: 1:1000
• Nº de acceso NCBI: NP_001096.1
• Nº de acceso UniProt: Q04771
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ACVR1(90)

Descripción

Descripción general

Activin A receptor type 1 (ACVR1) gene encodes a transmembrane protein that belongs to the bone morphogenetic protein (BMP) type I receptors subfamily of the transforming growth factor-β (TGF-β) receptors. ACVR1 is a single-pass type I membrane protein with a ligand-binding extracellular domain, a transmembrane domain, and a cytoplasmic domain. ACVR1 gene is expressed abundantly in endothelial cells, parenchymal cells, fibroblasts, and tumor-derived epithelial cells. This gene is located on human chromosome 2q24.1.

Aplicación

Anti-Activin receptor type IA (ACVR1) (CENTER R147) antibody produced in rabbit has been used in immunohistochemistry (1:100) and western blot (1:100).

Acciones bioquímicas o fisiológicas

Activin A receptor type 1 (ACVR1) protein can bind activin in concert with activin receptor type 2 (ActRII) or activin receptor type-2B (ActRIIB). It participates in activin signaling. It is also capable of forming a complex with either the bone morphogenetic protein (BMP)-2/7-bound bone morphogenetic protein receptor type II (BMPR-II) or activin A receptor type 2A/2B (ACVR2A/ACVR2B). Somatic mutations of the ACVR1 gene are associated with primary ovary and colon cancer. It is considered a target gene to fibrodysplasia ossificans progressiva (FOP).

Forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable