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MAK034

Sigma-Aldrich

Coenzyme A (CoA) Assay Kit

sufficient for 100 colorimetric or fluorometric tests

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About This Item

Código UNSPSC:
12161503
NACRES:
NA.84

uso

sufficient for 100 colorimetric or fluorometric tests

método de detección

colorimetric
fluorometric

grupo funcional

phospholipid

enfermedades relevantes

endocrinological disorders, diabetes; cancer

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Descripción general

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP (adenosine triphosphate). CoA plays important roles in many metabolic pathways, including the Tricarboxylic Acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example Acetyl-CoA, are critical intermediates in many metabolic reactions, particularly fatty acid and carbohydrate metabolism. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

Aplicación

Coenzyme A (CoA) Assay Kit has been used to measure CoA levels.

Características y beneficios

Compatible with high-throughput handling systems.

Idoneidad

Suitable for the measurement of Coenzyme A (CoA) in a variety of biological samples including cell and tissue lysates

Principio

The Coenzyme A Assay kit is an easy and convenient assay to measure the CoA level in a variety of biological samples. CoA concentration is determined by an enzymatic assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535 nm/λem = 587 nm) product, proportional to the CoA present. Typical sensitivities of detection for this kit are 0.1-10 nmol of CoA.

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Referencia del producto
Descripción
Precios

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H319 - H334

Clasificaciones de peligro

Eye Irrit. 2 - Resp. Sens. 1

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

188.6 °F - closed cup

Punto de inflamabilidad (°C)

87 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.
Current Opinion in Cell Biology, 33, 125-131 (2015)
ATP-citrate lyase: a key player in cancer metabolism.
Zaidi N, et al.
Cancer Research (2012)
The subcellular localization of acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Proceedings of the National Academy of Sciences of the USA, 97(4), 1444-1449 (2000)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
Abu-Elheiga L, et al.
Science, 291(5513), 2613-2616 (2001)
Long-Chain Fatty Acyl-CoA Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.
Rosen B C, et al.
Antimicrobial Agents and Chemotherapy, AAC-02130 (2016)
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