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E0907

Sigma-Aldrich

Anti-phospho-Epidermal Growth Factor Receptor (pTyr845) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-phospho-EGFR (pTyr845)

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About This Item

Número MDL:
MFCD03845329
Código UNSPSC:
51111800

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

lyophilized powder

reactividad de especies

human

técnicas

flow cytometry: 5 μg/mL
immunohistochemistry: 15 μg/mL
western blot: 0.5 μg/mL

Nº de acceso UniProt

P00533

temp. de almacenamiento

−20°C

Información sobre el gen

human ... EGFR(1956)

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Inmunógeno

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 845 of human epidermal growth factor receptor.

Acciones bioquímicas o fisiológicas

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Phosphorylation of Tyr845 is associated with EGFR mutation and serves as a surrogate marker.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Hideki Endoh et al.
Lung cancer (Amsterdam, Netherlands), 63(2), 241-246 (2008-07-01)
Overexpression of EGFR is found in several malignancies including lung cancers. Recently, EGFR mutation has been shown to correlate with responsiveness to tyrosine kinase inhibitors (TKI). Although antibodies against phophorylated EGFR have been used in vitro, phosphorylated EGFR has yet
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Javier Palazuelos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 11884-11896 (2014-09-05)
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination. Our study identifies ADAM17, also called tumor necrosis
Lakshmi Reddy Bollu et al.
Cell cycle (Georgetown, Tex.), 13(15), 2415-2430 (2014-12-09)
Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as
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