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C4116

Sigma-Aldrich

Cyclopamine hydrate

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

Sinónimos:

11-deoxojervine hydrate

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About This Item

Fórmula empírica (notación de Hill):
C27H41NO2 · xH2O
Número de CAS:
1217465-07-0
Peso molecular:
411.62 (anhydrous basis)
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
24724439
NACRES:
NA.77

product name

Cyclopamine hydrate, ≥98% (HPLC)

Análisis

≥98% (HPLC)

formulario

solid

color

white

solubilidad

DMSO: soluble ≥5 mg/mL
H2O: insoluble

temp. de almacenamiento

2-8°C

cadena SMILES

O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1

InChI

1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1

Clave InChI

KDAGJRDPNXDDSB-HBYCUIHISA-N

Información sobre el gen

human ... EBP(10682)

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Descripción general

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Aplicación

Cyclopamine hydrate has been used:
  • as a sonic hedgehog (Shh) inhibitor in various experiments
  • to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
  • to study its influence on ocular vessel patterning

Acciones bioquímicas o fisiológicas

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sonic Hedgehog human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3156

Sonic Hedgehog human

Smoothened Agonist, SAG A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).

Sigma-Aldrich

566660

Smoothened Agonist, SAG

FF-MAS Avanti Research™ - A Croda Brand

Avanti

700077P

FF-MAS

HPI-4 ≥98% (HPLC)

Sigma-Aldrich

H4541

HPI-4

GANT61 ≥98% (HPLC)

Sigma-Aldrich

G9048

GANT61

Valproic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1061

Valproic acid

Dorsomorphin ≥98% (HPLC)

Sigma-Aldrich

P5499

Dorsomorphin

Carlos Andrés Chacón-Martínez et al.
The EMBO journal, 36(2), 151-164 (2016-12-13)
Understanding how complex tissues are formed, maintained, and regenerated through local growth, differentiation, and remodeling requires knowledge on how single-cell behaviors are coordinated on the population level. The self-renewing hair follicle, maintained by a distinct stem cell population, represents an
Regulatory Mechanisms of the Ihh/PTHrP Signaling Pathway in Fibrochondrocytes in Entheses of Pig Achilles Tendon
Han X, et al.
Stem Cells International, 2016 (2016)
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway
Li S, et al.
Journal of Cellular and Molecular Medicine, 22(1), 230-240 (2018)
Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity
Munoz-Bravo JL, et al
Testing, 11(10), e0164714-e0164714 (2016)
Introduction to Cancer Metastasis (2016)
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