C0737

Cilostazol

≥98% (HPLC), powder

• Sinónimos: 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal
• Fórmula empírica (notación de Hill): C₂₀H₂₇N₅O₂
• Número de CAS: 73963-72-1
• Peso molecular: 369.46
• Número MDL: MFCD00866780
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24278291
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• color: off-white
• solubilidad: DMSO: 10 mg/mL, clear
• emisor: Otsuka Pharma
• cadena SMILES: O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1
• InChI: 1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
• Clave InChI: RRGUKTPIGVIEKM-UHFFFAOYSA-N
• Información sobre el gen: human ... PDE3A(5139) , PDE3B(5140)

Descripción

Descripción general

Cilostazol prevents platelet aggregation and has vasodilatory properties. It is used to treat chronic arterial disease and intermittent claudication. Cilostazol has antiproliferative effects and improves the properties of prostacyclin. It regulates cell proliferation, stimulates cyclic adenosine monophosphate (cAMP) level and induces cyclic AMP-dependent protein kinase.

Aplicación

Cilostazol has been used:

• to reduce Madin–Darby cell line (MDCK) proliferation through c-Myc down-regulation
• in the in vitro assessment of toxin delivery in T84 intestinal epithelial cells
• to induce adenosine triphosphate (ATP) release in white adipocytes

Acciones bioquímicas o fisiológicas

Phosphodiesterase III (PDE3) inhibitor

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Otsuka Pharma. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H361d
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)