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Key Documents

301M-1

Sigma-Aldrich

Cytokeratin, LMW (AE1) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

AE1, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (301M-14)
vial of 0.5 mL concentrate (301M-15)
bottle of 1.0 mL predilute (301M-17)
vial of 1.0 mL concentrate (301M-16)
bottle of 7.0 mL predilute (301M-18)

fabricante / nombre comercial

Cell Marque

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG1κ

control

prostate

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Información sobre el gen

human ... KRT1(3848)

Categorías relacionadas

Descripción general

Anti-cytokeratin, low molecular weight (AE1) labels most acidic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. Members of the acidic and basic cytokeratin subfamilies are found together in pairs; each epithelium contains at least one acidic and one basic keratin so this antibody can show the distribution of keratin containing cells in epithelia. This antibody has shown great sensitivity and broad specificity for keratins under various conditions of fixation and staining. Anti-low molecular weight cytokeratin (AE1) is particularly suited to distinguish poorly differentiated carcinomas from non-epithelial neoplasms. This marker stains both normal and neoplastic cells of epithelial origin.

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

Cytokeratin, LMW Positive Control Slides, Product No. 301S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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A R Judkins et al.
American journal of clinical pathology, 110(5), 641-646 (1998-11-05)
Immunohistochemistry occasionally is used to determine the lineage of entirely necrotic tumors. However, the sensitivity and specificity of antibodies on necrotic tissue are unknown. To determine the usefulness of immunohistochemistry with necrotic lesions, a series of 24 known tumors consisting
R Kitazawa et al.
Virchows Archiv : an international journal of pathology, 435(2), 137-142 (1999-12-22)
A 69-year-old man had a hepatic tumour occupying the left and half of the right lobe, with portal vein thrombus. There were hypercalcaemia and hypophosphataemia with increased nephrogenous cyclic adenosine monophosphate; bone metastases were excluded. Serum parathyroid hormone-related protein (PTHrP)
A J Demetris et al.
The American journal of pathology, 149(2), 439-448 (1996-08-01)
The ductular reaction to acute submassive necrosis was studied in human livers removed at the time of orthotopic liver transplantation. Single, double, and triple immunohistochemical labeling in combination with morphometry was used to analyze the phenotype and proliferative and apoptotic
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 166-174 (2002)
V Eusebi et al.
The American journal of surgical pathology, 14(8), 737-747 (1990-08-01)
We present four cases of a malignant thyroid tumor showing morphologic, immunocytochemical, and ultrastructural features of endothelial cell differentiation. The tumor cells had epithelioid features and displayed strong immunoreactivity for keratin. There was no evidence of follicular or C-cell differentiation

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