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Documentos

Y0001263

Etacrynic acid for system suitability

Name: Etacrynic acid for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Ethacrynic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

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About This Item

Fórmula empírica (notación de Hill):

C₁₃H₁₂Cl₂O₄

Número de CAS:

58-54-8

Peso molecular:

303.14

Número MDL:

MFCD00056693

Código UNSPSC:

41116107

ID de la sustancia en PubChem:

329831330

NACRES:

NA.24

grado

pharmaceutical primary standard

familia API

etacrynic acid

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

Clave InChI

AVOLMBLBETYQHX-UHFFFAOYSA-N

Información sobre el gen

human ... SLC12A1(6557)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Etacrynic acid for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Consejos de prudencia

P264 - P270 - P301 + P312 - P501

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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[Action and mode of action of a new original diuretic: ethacrynic acid].

M Salvador et al.

Journal de medecine de Bordeaux et du Sud-Ouest, 143(8), 1105-1118 (1966-08-01)

Toxicity of ethacrynic acid and furosemide.

L B Cooperman et al.

American heart journal, 85(6), 831-834 (1973-06-01)

Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases.

J H Ploemen et al.

Xenobiotica; the fate of foreign compounds in biological systems, 23(8), 913-923 (1993-08-01)

1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (microM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively. 2. The reversible inhibition by the glutathione

Ototoxicity of ethacrynic acid (a persistent clinical problem).

L P Rybak

The Journal of laryngology and otology, 102(6), 518-520 (1988-06-01)