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Key Documents

MAB1876

Sigma-Aldrich

Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1)

clone 27.1 (VNR-1), Chemicon®, from mouse

Sinónimos:

CD51/CD61, VNR-1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

27.1 (VNR-1), monoclonal

reactividad de especies

human

fabricante / nombre comercial

Chemicon®

técnicas

immunofluorescence: suitable
immunoprecipitation (IP): suitable

isotipo

IgG1

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ITGAV(3685)

Especificidad

Reacts with the human integrin alphaVbeta3. Shown to be specific for alphaVbeta3 by Loftus JC et al (1990) Science 249:915-918.

Aplicación

Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1) detects level of Integrin αVβ3 & has been published & validated for use in IF & IP.
Immunohistochemistry: 4-10% formalin fixed frozen tissues (short fixation times, 10 minutes room temperature) only; not effective on paraffin embedded tissues

Immunoprecipitation

Functional blocking: Competes with clone LM609 for integrin function blocking.



Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Forma física

Format: Purified
Protein A purified mouse immunoglobulin in liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.

Almacenamiento y estabilidad

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Dynamic regulation of integrins.
Faull, R J and Ginsberg, M H
Stem Cells, 13, 38-46 (1995)
Dake Hao et al.
Frontiers in bioengineering and biotechnology, 8, 890-890 (2020-08-28)
Endothelial cell (EC) transplantation via injectable collagen hydrogel has received much attention as a potential treatment for various vascular diseases. However, the therapeutic effect of transplanted ECs is limited by their poor viability, which partially occurs as a result of
Kouki Morizono et al.
Journal of virology, 88(8), 4275-4290 (2014-01-31)
We recently demonstrated that a soluble protein, Gas6, can facilitate viral entry by bridging viral envelope phosphatidylserine to Axl, a receptor tyrosine kinase expressed on target cells. The interaction between phosphatidylserine, Gas6, and Axl was originally shown to be a
Handong Ma et al.
Cell reports, 30(3), 793-806 (2020-01-23)
Periostin is a multifunctional extracellular matrix protein involved in various inflammatory diseases and tumor metastasis; however, evidence regarding whether and how periostin actively contributes to inflammation-associated tumorigenesis remains elusive. Here, we demonstrate that periostin deficiency significantly inhibits the occurrence of

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