FCMAB288A6

Milli-Mark^® Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor^™647, clone Apu3

clone Apu3, Milli-Mark^®, from rabbit

• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: ALEXA FLUOR^™ 647
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: Apu3, monoclonal
• reactividad de especies: human
• fabricante / nombre comercial: Milli-Mark^®
• técnicas: flow cytometry: suitable
• isotipo: IgG
• Nº de acceso UniProt: P0CG48
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... UBB(7314)

Descripción

Descripción general

Polyubiquitin chains linked through the Lys48 residue of ubiquitin are most commonly associated with proteins targeted for proteosomal degradation. In contrast, polyubiquitin chains linked through the Lys63 residue of ubiquitin (Ub) are associated with nonproteolytic functions such as signal transduction. Lys63-linked polyUb chains connect components of NFκB signaling in a highly regulated manner, and genetic evidence indicates the involvement of Lys63-linked Ub chains in stress response and DNA repair. Research in yeast has suggested Lys63-linked Ub chains stimulate endocytosis.

Especificidad

Recognizes ubiquitin linked at Lys63. Does not recognize ubiquitin linked at Lys48 or free ubiquitin.

Inmunógeno

Immunogen used was di-ubiquitin linked at Lys63.

Aplicación

This Milli-Mark Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3 is validated for use in FC for the detection of Ubiquitin.

Calidad

Evaluated by flow cytometry using HeLa cells

Descripción de destino

Molecular weight varies.

Forma física

Purified recombinant rabbit monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Información legal

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable