ABS453

Anti-CHD7 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Chromodomain helicase DNA binding protein 7, CHD-7, IS3, KAL5, ATP-dependent helicase CHD7
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse, human
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: Q9P2D1
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CHD7(55636)

Descripción

Descripción general

Chromodomain-helicase-DNA-binding protein 7 (CHD7), also known as ATP-dependent helicase CHD7, belongs to a superfamily of proteins of the ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. CHD7 may play an important role in early embryonic development by affecting chromatin structure and gene expression. CHD7 interacts with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes. Defects in CHD7 are suggested to be the cause of CHARGE syndrome (CHARGES) and idiopathic scoliosis type 3 (IS3). Mutations in CHD7 may also result in hypogonadotropic hypogonadism (HH5). CHD7 is widely expressed in fetal and adult tissues.

Inmunógeno

KLH-conjugated linear peptide corresponding to human CHD7.

Aplicación

Anti-CHD7 Antibody is a highly specific rabbit polyclonal antibody, that targets CHD7 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected CHD7 in mouse brain tissue.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Calidad

Evaluated by Western Blotting in SK-N-SH cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected CHD7 in 15 µg of SK-N-SH cell lysate.

Descripción de destino

~290 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~128 kDa and ~336 kDa

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
SK-N-SH cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable