8.52202

Fmoc-Trp(Boc)-Ser(psiMe,Mepro)-OH

Novabiochem^®

• Sinónimos: Fmoc-Trp(Boc)-Ser(psiMe,Mepro)-OH
• Fórmula empírica (notación de Hill): C₃₇H₃₉N₃O₈
• Número de CAS: 908601-15-0
• Peso molecular: 653.72
• Código UNSPSC: 12352209
• NACRES: NA.22

Propiedades

• Nivel de calidad: 200
• Línea del producto: Novabiochem^®
• Análisis: ≥97% (TLC); ≥97.0% (HPLC)
• formulario: powder
• idoneidad de la reacción: reaction type: Fmoc solid-phase peptide synthesis
• fabricante / nombre comercial: Novabiochem^®
• aplicaciones: peptide synthesis
• grupo funcional: hydroxyl
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C37H39N3O8/c1-36(2,3)48-35(45)39-19-22(23-12-10-11-17-30(23)39)18-29(32(41)40-20-31(33(42)43)47-37(40,4)5)38-34(44)46-21-28-26-15-8-6-13-24(26)25-14-7-9-16-27(25)28/h6-17,19,28-29,31H,18,20-21H2,1-5H3,(H,38,44)(H,42,43)/t29-,31-/m0/s1
• Clave InChI: VHFFWLZYMVKHDX-SMCANUKXSA-N

Descripción

Descripción general

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Trp-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Ligadura / enlace

Replaces: 05-20-1130

Nota de análisis

Colour (visual): white to yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -39.5 - -34.5 °
Purity (TLC(CMA2)): ≥ 97 %
Purity (TLC(157A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Single impurities (HPLC, area%): ≤ 1.00 % (a/a)
Ethyl acetate (HS-GC): ≤ 2.0 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Información legal

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable