5677

Spermine, Tetrahydrochloride

• Sinónimos: Spermine, Tetrahydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₂₆N₄ · 4HCl
• Número de CAS: 306-67-2
• Peso molecular: 348.18
• Número MDL: MFCD00012914
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥99% (titration)
• Nivel de calidad: 100
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: water: 20 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clave InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Descripción

Descripción general

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.

Acciones bioquímicas o fisiológicas

Primary Target
phospholipase C α

Secondary Target
nNOS

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.

Otras notas

Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.
Ask, A., et al. 1992. Cancer Lett.66, 29.
Chida, N., et al. 1992. Brain Res.593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.
Shantz, L.M., et al. 1992. Biochem. J.288, 511.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable