420360-M

KMO Inhibitor I, Ro 61-8048

The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinónimos: KMO Inhibitor I, Ro 61-8048, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
• Fórmula empírica (notación de Hill): C₁₇H₁₅N₃O₆S₂
• Número de CAS: 199666-03-0
• Peso molecular: 421.45
• Número MDL: MFCD11040807
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥99% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 100 mg/mL; ethanol: 12.5 mg/mL
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
• Clave InChI: NDPBMCKQJOZAQX-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (K_i = 4.8 nM; IC₅₀ = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.
Giorgini, F., et al. 2005. Nat. Genet.37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab.19, 771,
Rover, S., et al. 1997. J. Med. Chem.40, 4378.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3