344273-M

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride

Chemically-modified forskolin with greater stability and water solubility than the parent compound.

• Sinónimos: Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
• Fórmula empírica (notación de Hill): C₂₉H₄₈N₂O₇ · 2HCl
• Número de CAS: 115116-37-5
• Peso molecular: 609.62
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 200
• Análisis: ≥92% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 12 mg/mL; methanol: soluble
• temp. de almacenamiento: 10-30°C

Descripción

Descripción general

A chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC₅₀ = 13 µM).

Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC₅₀ = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.

Acciones bioquímicas o fisiológicas

EC50 = 13 µM in activating adenylate cyclase

Primary Target
Adenylate cyclase

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Otras notas

Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol.41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol.23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol.32, 133.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable