14-418
p300, HAT Domain
Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
mol peso
Mw 100 kDa
fabricante / nombre comercial
Upstate®
técnicas
activity assay: suitable (histone acetyltransferase (HAT))
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
Información sobre el gen
human ... EP300(2033)
Descripción general
Product Source: Expressed in E. coli.
Aplicación
Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.
Calidad
Routinely evaluated by HAT Assay.
Definición de unidad
Specific Activity: 1 Unit is defined as the transfer of 1nmol of [3H]-acetate/minute to acid-extracted histones.
Almacenamiento y estabilidad
-20°C for up to 6 months from the date of receipt.
Otras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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A Giordano et al.
Journal of cellular physiology, 181(2), 218-230 (1999-09-25)
p300 and CBP are highly related nuclear proteins, which have been implicated in transcriptional responses to disparate extracellular and intracellular signals. There are at least two very good reasons for which p300 and CBP have attracted the attention of the
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
Weibin Wang,Kewu Pan,Yifan Chen,Chunyin Huang,Xiaowei Zhang
Nucleic Acids Research null
Dennis Shin-Shian Hsu et al.
Cancer cell, 26(4), 534-548 (2014-10-15)
Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein
R L Schiltz et al.
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Junhui Xue et al.
Cancer letters, 471, 12-26 (2019-12-08)
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. AFP acetylation was regulated by the acetyltransferase CBP and the deacetylase SIRT1. Acetylation of AFP at lysines 194, 211, and
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