05-1938

Anti-G3BP1 Antibody, clone 14E5-G9

clone 14E5-G9, from mouse

• Sinónimos: ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, GAP binding protein, GTPase activating protein (SH3 domain) binding protein 1, Ras-GTPase-activating protein SH3-domain-binding protein, RasGAP-associated endoribonuclease G3BP
• Código UNSPSC: 12352203
• eCl@ss: 32160702

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: 14E5-G9, monoclonal
• reactividad de especies: human
• técnicas: immunocytochemistry: suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_005745.1
• Nº de acceso UniProt: Q13283
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... G3BP1(10146)

Descripción

Descripción general

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.

Especificidad

This antibody recognizes G3BP1.

Inmunógeno

GST-tagged recombinant protein corresponding to human G3BP1.

Aplicación

Anti-G3BP1 Antibody, clone 14E5-G9 is an antibody against G3BP1 for use in WB & IC.

Research Sub Category
RNA Metabolism & Binding Proteins

G-proteins

Calidad

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate.

Descripción de destino

52 kDa

Forma física

Format: Purified

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable