B-054

Buspirone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₂₁H₃₁N₅O₂ · HCl
• Número de CAS: 33386-08-2
• Peso molecular: 421.96
• Número MDL: MFCD00078569
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329773117
• NACRES: NA.24

Propiedades

• grado: certified reference material
• Nivel de calidad: 300
• formulario: liquid
• Características: (Snap-N-Spike^®)
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 1.0 mg/mL in methanol (as free base)
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing
• formato: single component solution
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C1CC2(CCCC2)CC(N1CCCCN(CC3)CCN3C4=NC=CC=N4)=O.Cl
• InChI: 1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
• Clave InChI: RICLFGYGYQXUFH-UHFFFAOYSA-N
• Información sobre el gen: human ... HTR1A(3350)

Descripción

Descripción general

Buspirone, sold under the trade name Buspar^®, is an antidepressant marketed for treatment of generalized anxiety disorder and clinical depression. Suitable uses for this Certified Spiking Solution^®include as starting material for calibrators and controls in antidepressant testing methods by LC/MS or GC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

Aplicación

• Optimization of Buspirone Hydrochloride-Loaded In Situ Gel for Pediatric Anxiety: This study utilized response surface methodology to develop an optimized formulation of buspirone hydrochloride in situ gel, specifically designed for pediatric anxiety treatment. (Abdallah et al., 2022).


• Behavioral Effects of Buspirone in Juvenile Zebrafish: Investigating the behavioral effects of buspirone on juvenile zebrafish of two different genetic backgrounds, this study highlights the potential of buspirone hydrochloride solution to serve as a critical tool in neuropharmacological research, especially in studying anxiolytic compounds and their mechanisms of action within the GABAergic system (Abozaid et al., 2022).


• Nasal Delivery System for Buspirone Hydrochloride: Focused on the development of buspirone hydrochloride-loaded nanovesicular gels for nasal delivery, this research explores an innovative approach to administering psychiatric medication, providing a promising alternative to traditional oral routes. This method could potentially enhance the bioavailability and onset of action of buspirone, making it more effective for treating anxiety disorders (Abdelnabi et al., 2019).

Información legal

Buspar is a registered trademark of Bristol-Myers Squibb Co.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225 - H301 + H311 + H331 - H370
• Consejos de prudencia: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup