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ALD00606

Sigma-Aldrich

Wang−Yu non-directed C−H functionalization ligand

95%

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About This Item

Fórmula empírica (notación de Hill):
C7H3F6NO
Número de CAS:
38609-76-6
Peso molecular:
231.10
Número MDL:
MFCD28802532
Código UNSPSC:
12352200
NACRES:
NA.22

Análisis

95%

formulario

powder or crystals

idoneidad de la reacción

reaction type: C-C Bond Formation
reagent type: catalyst
reaction type: C-H Activation

mp

145 °C

temp. de almacenamiento

−20°C

Categorías relacionadas

Aplicación

This 2-pyridone ligand developed in the laboratory of Jin-Quan Yu binds to palladium and accelerates non-directed C-H functionalization. Developed for C-H olefination and carboxylation with arene as the limiting reagent, the Wang-Yu ligand enables diversification of drugs, synthetic intermediates, and other bioactive small molecules.

Otras notas

Ligand-accelerated non-directed C-H functionalization of arenes

Ligand-Promoted meta-C-H Functionalization of Benzylamines

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Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jin Lin et al.
Nature communications, 8, 14353-14353 (2017-02-07)
Catalytic oxidative C-H bond functionalization reactions that proceed without requiring stoichiometric amounts of external oxidants or pre-functionalized oxidizing reagents could maximize the atom- and step-economy in chemical syntheses. However, such a transformation remains elusive. Here, we report that a photo-driven
Peng Wang et al.
Nature, 551(7681), 489-493 (2017-11-24)
The directed activation of carbon-hydrogen bonds (C-H) is important in the development of synthetically useful reactions, owing to the proximity-induced reactivity and selectivity that is enabled by coordinating functional groups. Palladium-catalysed non-directed C-H activation could potentially enable further useful reactions
Direct perfluoroalkylation including trifluoromethylation of aromatics with perfluoro carboxylic acids mediated by xenon difluoride.
Tanabe Y, et al.
The Journal of Organic Chemistry, 53 (19), 4582?4585-4582?4585 (1988)
Peng Wang et al.
Angewandte Chemie (International ed. in English), 56(18), 5125-5129 (2017-04-04)
Meta-C-H functionalization of benzylamines has been developed using a PdII /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is

Contenido relacionado

Yu Group – Professor Product Portal

The Yu program centers around the discovery of catalytic carbon–carbon and carbon–heteroatom bond forming reactions based on C–H activation. Target transformations are selected to enable 1) the use of simple and abundant starting materials such as aliphatic acids, amines and alcohols, and 2) disconnections that drastically shorten the synthesis of a drug molecule or a major class of biologically active compounds.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico