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SMAD4

SMAD family member 4

Sinónimos:
DPC4, JIP, MADH4, MYHRS
Especie:
ID UniProtKB:
ID del gen:
  • Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
  • Mouse(17128) SMAD family member 4
  • Rat(50554) SMAD family member 4
  • Zebrafish(30640) MAD homolog 4 (Drosophila)
  • Horse(100033846) SMAD family member 4
  • domestic cat(101093650) SMAD family member 4
  • dog(476196) SMAD family member 4
  • naked mole-rat(101703764) SMAD family member 4
  • domestic guinea pig(100717853) SMAD family member 4
  • cow(540248) SMAD family member 4
  • sheep(443171) SMAD family member 4
  • Goat(100861019) SMAD family member 4

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ELISA

Referencia del producto
Descripción
Especie
Human Smad4 ELISA, for serum, plasma and cell culture supernatants,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-SMAD4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 4G1C6, ascites fluid,
Reactividad de especies
human
Aplicación
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-SMAD4 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM277, purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-SMAD4 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat, sheep
Aplicación
immunohistochemistry
western blot
Anti-Smad4/DPC4 Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
chimpanzee, human, mouse, rat
Aplicación
immunocytochemistry
western blot

Proteins

Referencia del producto
Descripción
Especie
SMAD4, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Smad4,
Especie
mouse
MISSION® esiRNA, targeting human SMAD4,
Especie
human