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Merck

PRKCA

protein kinase C, alpha

Sinónimos:
AAG6, PKC-alpha, PKCA, PRKACA
Especie:
Human PRKCA (5578), Mouse Prkca (18750), Rat Prkca (24680), cow PRKCA (282001), sheep PRKCA (101110074), naked mole-rat Prkca (101716044), Domestic Rabbit PRKCA (100037720), domestic guinea pig Prkca (100302324), domestic guinea pig Prkca (100713627), Zebrafish prkca (497384) ...Más
ID UniProtKB:
P17252, B5BU22, Q15137, Q32M72, Q96RE4
ID del gen:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha

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Small Molecule - Activator

Referencia del producto
Descripción
Especie
20-133-M
PKC Lipid Activator, ,
Especie
human

Small Molecule - Agonist

Referencia del producto
Descripción
Especie
O1008
Ácido oleico, ≥99% (GC),
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB4502354
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
western blot
SAB4200739
Anti-Protein kinase C antibody, Mouse monoclonal, clone MC5, purified from hybridoma cell culture,
Reactividad de especies
bovine, chicken, fish, human, mouse, rabbit, rat
Aplicación
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
05-983
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
SAB4502356
Anti-PKC-PAN antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot
07-790
Anti-phospho-PKCα (Ser657/Tyr658) Antibody, Upstate®, from rabbit,
Reactividad de especies
human, rabbit, rat
Aplicación
ELISA
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
S7049
D-Sphingosine, synthetic,
Especie
rat
O6754
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
Especie
human
K1639
K-252a, from Nonomuraea longicatena, ≥98% (HPLC),
Especie
rat, human
K2015
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Especie
rat, human
C9911
(S)-(+)-Camptothecin, ≥90% (HPLC), powder,
Especie
rat, mouse, human

Proteins

Referencia del producto
Descripción
Especie
14-484-M
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Especie
human
P1782
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Especie
human
SRP5251
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie

esiRNA

Referencia del producto
Descripción
Especie
EMU080561
MISSION® esiRNA, targeting mouse Prkca,
Especie
mouse
EHU050821
MISSION® esiRNA, targeting human PRKCA,
Especie
human

Small Molecule - Substrate

Referencia del producto
Descripción
Especie
20-131
PKC Substrate Cocktail, ,
Especie
human
12-123
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
Especie
human