MAP3K3
mitogen-activated protein kinase kinase kinase 3
Sinónimos:
MAPKKK3, MEKK3
Especie:
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), Zebrafish map3k3 (560211), chicken MAP3K3 (419954), domestic cat MAP3K3 (101083633), cow MAP3K3 (508943) ...Más
ID UniProtKB:
ID del gen:
- Human(4215) Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(26406) mitogen-activated protein kinase kinase kinase 3
- Rat(303604) mitogen activated protein kinase kinase kinase 3
- naked mole-rat(101704335) mitogen-activated protein kinase kinase kinase 3
- domestic guinea pig(100731994) mitogen-activated protein kinase kinase kinase 3
- sheep(101122537) mitogen-activated protein kinase kinase kinase 3
- Zebrafish(560211) mitogen-activated protein kinase kinase kinase 3
- chicken(419954) mitogen-activated protein kinase kinase kinase 3
- domestic cat(101083633) mitogen-activated protein kinase kinase kinase 3
- cow(508943) mitogen-activated protein kinase kinase kinase 3
- Horse(100064751) mitogen-activated protein kinase kinase kinase 3
- dog(480481) mitogen-activated protein kinase kinase kinase 3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-MAP3K3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-MAP3K3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
proximity ligation assay
western blot
western blot
Monoclonal Anti-MAP3K3 antibody produced in mouse, clone 1H3, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot
Proteins
Referencia del producto
Descripción
Especie
MEKK3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human