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Merck

HP

haptoglobin

Sinónimos:
BP, HP2ALPHA2, HPA1S
Especie:
ID UniProtKB:
ID del gen:
  • Human(3240) Summary: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(15439) haptoglobin
  • Rat(24464) haptoglobin
  • Zebrafish(566096) haptoglobin
  • fruit fly(251278) humped
  • dog(479668) haptoglobin
  • cow(280692) haptoglobin
  • domestic cat(100144610) haptoglobin
  • domestic guinea pig(100721435) haptoglobin
  • naked mole-rat(101705743) haptoglobin
  • sheep(101102413) haptoglobin
  • Domestic Rabbit(100008816) haptoglobin

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Haptoglobin antibody produced in rabbit, IgG fraction of antiserum, lyophilized powder,
Reactividad de especies
human
Aplicación
ELISA
Anti-Haptoglobin antibody, Mouse monoclonal, clone HG-36, purified from hybridoma cell culture,
Reactividad de especies
human
Aplicación
ELISA
dot blot

immunoprecipitation (IP)

western blot
Monoclonal Anti-Haptoglobin antibody produced in mouse, clone HG-36, ascites fluid,
Reactividad de especies
human
Aplicación
ELISA
Anti-Haptoglobin (HP) antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-Hp Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación

Proteins

Referencia del producto
Descripción
Especie
Haptoglobin from pooled human plasma, ≥95% (SDS-PAGE), lyophilized powder,
Especie
human
Haptoglobin Human, Phenotype 1-1, 98-100%, essentially salt-free, lyophilized powder,
Especie
human
Haptoglobin (Phenotype 1-1) from human plasma, ≥95% (SDS-PAGE),
Especie
human
Haptoglobin Plasma (MixedType) from human plasma, ≥95% (SDS-PAGE),
Especie
human
Haptoglobin (Phenotype 2-2) from human plasma, ≥95% (SDS-PAGE),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human HP,
Especie
human