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Merck

HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

Sinónimos:
HL
Especie:
Human HMGCL (3155), Mouse Hmgcl (15356), Rat Hmgcl (79238), Zebrafish hmgcl (394190), chicken HMGCL (396316), dog HMGCL (478187), domestic cat HMGCL (101099569), cow HMGCL (317658), domestic guinea pig Hmgcl (100713291), naked mole-rat Hmgcl (101716848)
ID UniProtKB:
P35914, B4DUP4, B7UCC6, D3Y5K7, Q6IBC0, Q96FP8
ID del gen:
  • Human(3155) Summary: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(15356) 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
  • Rat(79238) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • Zebrafish(394190) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
  • chicken(396316) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • dog(478187) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • domestic cat(101099569) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • cow(317658) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • domestic guinea pig(100713291) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • naked mole-rat(101716848) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • sheep(101119699) 3-hydroxymethyl-3-methylglutaryl-CoA lyase

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA004727
Anti-HMGCL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
SAB1410639
Anti-HMGCL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
M2537
Mevastatin, ≥98% (HPLC), powder or crystals,
Especie
rat, human

esiRNA

Referencia del producto
Descripción
Especie
EMU050141
MISSION® esiRNA, targeting mouse Hmgcl,
Especie
mouse