GALE
UDP-galactose-4-epimerase
Sinónimos:
SDR1E1
Especie:
Human GALE (2582), Mouse Gale (74246), Rat Gale (114860), Zebrafish gale (678540), chicken GALE (419686), fruit fly Gale (38076), dog GALE (487373), cow GALE (523154), domestic cat GALE (101099312), domestic guinea pig Gale (100722082) ...Más
ID UniProtKB:
ID del gen:
- Human(2582) Summary: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- Mouse(74246) galactose-4-epimerase, UDP
- Rat(114860) UDP-galactose-4-epimerase
- Zebrafish(678540) UDP-galactose-4-epimerase
- chicken(419686) UDP-galactose-4-epimerase
- fruit fly(38076) UDP-galactose 4'-epimerase
- dog(487373) UDP-galactose-4-epimerase
- cow(523154) UDP-galactose-4-epimerase
- domestic cat(101099312) UDP-galactose-4-epimerase
- domestic guinea pig(100722082) UDP-galactose-4-epimerase
- naked mole-rat(101714632) UDP-galactose-4-epimerase
- sheep(101120144) UDP-galactose-4-epimerase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-GALE antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-GALE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Gale Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence