CDK4
cyclin-dependent kinase 4
Sinónimos:
CMM3, PSK-J3
Especie:
Human CDK4 (1019), Mouse Cdk4 (12567), Rat Cdk4 (94201), naked mole-rat Cdk4 (101702608), domestic guinea pig Cdk4 (100717960), sheep CDK4 (100144756), Domestic Rabbit CDK4 (100009039), Zebrafish cdk4 (777730), fruit fly Cdk4 (36854), cow CDK4 (510618) ...Más
ID UniProtKB:
ID del gen:
- Human(1019) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
- Mouse(12567) cyclin-dependent kinase 4
- Rat(94201) cyclin-dependent kinase 4
- naked mole-rat(101702608) cyclin-dependent kinase 4
- domestic guinea pig(100717960) cyclin-dependent kinase 4
- sheep(100144756) cyclin-dependent kinase 4
- Domestic Rabbit(100009039) cyclin-dependent kinase 4
- Zebrafish(777730) cyclin-dependent kinase 4
- fruit fly(36854) Cyclin-dependent kinase 4
- cow(510618) cyclin-dependent kinase 4
- domestic cat(101097903) cyclin-dependent kinase 4
- dog(481131) cyclin-dependent kinase 4
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-CDK4 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Phospho-CDK4-T172 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Anti-CDK4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-CDK4 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Reactividad de especies
human
Aplicación
western blot
Monoclonal Anti-CDK4 antibody produced in mouse, clone 4F11, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie
Proteins
Referencia del producto
Descripción
Especie
CDK4/Cyclin D1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
Especie
human
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
CDK4/CyclinD3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human