ALOX5
arachidonate 5-lipoxygenase
Sinónimos:
5-LO, 5-LOX, 5LPG, LOG5
Especie:
Human ALOX5 (240), Mouse Alox5 (11689), Rat Alox5 (25290), Zebrafish alox5 (573013), chicken ALOX5 (423769), dog ALOX5 (477753), domestic cat ALOX5 (101097422), cow ALOX5 (404074), Horse ALOX5 (100062042), Zebrafish alox5 (567204) ...Más
ID UniProtKB:
ID del gen:
- Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Mouse(11689) arachidonate 5-lipoxygenase
- Rat(25290) arachidonate 5-lipoxygenase
- Zebrafish(573013) arachidonate 5-lipoxygenase
- chicken(423769) arachidonate 5-lipoxygenase
- dog(477753) arachidonate 5-lipoxygenase
- domestic cat(101097422) arachidonate 5-lipoxygenase
- cow(404074) arachidonate 5-lipoxygenase
- Horse(100062042) arachidonate 5-lipoxygenase
- Zebrafish(567204) arachidonate 5-lipoxygenase
- domestic guinea pig(100718093) arachidonate 5-lipoxygenase
- naked mole-rat(101700210) arachidonate 5-lipoxygenase
- sheep(101117390) arachidonate 5-lipoxygenase
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-ALOX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ALOX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
western blot
western blot
Anti-5′-Lipoxygenase Antibody, Chemicon®, from rabbit,
Reactividad de especies
human, mouse, rabbit, rat
Aplicación
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-ALOX5-S271 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie