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[Severe flecainide acetate poisoning. Apropos of a case].

Archives des maladies du coeur et des vaisseaux (1999-03-17)
P Maury, C Vuille, J Metzger, B Veragut, I Schoenenberger, A Elamly, J C Chevrolet
ABSTRACT

Poisoning with flecainide acetate is rare and associated with a high mortality. This usually occurs after massive ingestion but can also be observed during therapeutic overdose in patients with renal failure or with amiodarone therapy. The prognostic depends on the haemodynamic and rhythmic effects of the overdose one sign of which is widening of the QRS complexes. Major sodium bicarbonate or lactate infusion is the generally prescribed treatment. The authors report one case of a patient with renal failure on amiodarone who survived a severe flecainide acetate overdose.

MATERIALS
Product Number
Brand
Product Description

Flecainide acetate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Flecainide acetate salt