- Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.
Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.
Organic letters (2014-03-22)
Masaki Itoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura
PMID24646166
ABSTRACT
The direct α-methylenation of benzylpyridines was achieved using N,N-dimethylacetamide (DMA) as a one-carbon source under copper catalysis. An intermediary species was detected at an early stage, and a possible mechanism was proposed. Additionally, α-oxygenation and dimerization of benzylpyridines could also be performed efficiently.
MATERIALS
Product Number
Brand
Product Description
USP
Residual Solvent Class 2 - N,N-Dimethylacetamide, United States Pharmacopeia (USP) Reference Standard
Pheniramine impurity A, European Pharmacopoeia (EP) Reference Standard