Skip to Content
Merck
All Photos(1)

Documents

SML1148

Sigma-Aldrich

YIL-781 hydrochloride

≥98% (HPLC)

Synonym(s):

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C24H28FN3O2 · xHCl
CAS Number:
875258-85-8
Molecular Weight:
409.50 (free base basis)
MDL number:
MFCD19690924
UNSPSC Code:
51111800
PubChem Substance ID:
329825682
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, white to yellow to light brown

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl

InChI

1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1

InChI key

QQGRMONBDBMLSP-FERBBOLQSA-N

Application

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.

Biochem/physiol Actions

YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Stewart Christie et al.
The Journal of physiology, 598(1), 139-150 (2019-10-24)
The fine control of food intake is important for the maintenance of a healthy metabolic state. Gastric vagal afferents (GVAs) are involved in the peripheral regulation of food intake via signalling the degree of distension of the stomach which ultimately

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service