Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

PZ0146

Sigma-Aldrich

SC-53116 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

4-Amino-5-chloro-N-[[(1S,7aS)-hexahydro-1H-pyrrolizin-1-yl]methyl]-2-methoxy-benzamide, SC 49518 hydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H22ClN3O2 · HCl · xH2O
CAS Number:
141196-99-8
Molecular Weight:
360.28 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329823731
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, white to yellow to brown

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]2CCN3CCCC23

InChI

1S/C16H22ClN3O2.ClH.H2O/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20;;/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21);1H;1H2/t10-,14-;;/m0../s1

InChI key

CZXMPKPHHWPFSI-UROSVOJDSA-N

Biochem/physiol Actions

SC-53116 is a 5-HT4 receptor partial agonist.
SC-53116 is a 5-HT4 receptor partial agonist. SC-53116 has been shown to ameliorate scopolamine-induced impairment in learning in rats at a does of 10 μg/rat i.c.v and increase population spike amplitude in the CA1 and CA3 fields of the hippocampus at the same concentration.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
114M4723V
090M4721

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

P G McLean et al.
Naunyn-Schmiedeberg's archives of pharmacology, 354(4), 513-519 (1996-10-01)
The effects of chronic infusion with 5-hydroxytryptamine (5-HT, 75 micrograms/kg per hour) for 5 or 10 days in vivo on the responses of rat oesophagus, fundus and jejunum to 5-HT and partial 5-HT receptor agonists in vitro were investigated. In
M Yamano et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(1), 145-150 (1997-07-01)
The influence of diabetic hyperglycemia on solid gastric emptying in rats was examined. Diabetes was produced by streptozotocin (STZ, 40 mg/kg i.v.), and diabetic hyperglycemia was observed from 1 day after the STZ injection. The gastric emptying of glass beads
Laurie B Schenkel et al.
Organic letters, 6(20), 3621-3624 (2004-09-25)
[reaction: see text] Highly diastereoselective intra- and intermolecular self-condensation reactions of N-tert-butanesulfinyl aldimines have been developed and applied to the rapid, asymmetric synthesis of trans-2-aminocyclopentanecarboxylic acid and the drug candidate SC-53116. Key to both syntheses is a novel microwave-assisted reaction
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.
D L Flynn et al.
Journal of medicinal chemistry, 35(8), 1486-1489 (1992-04-17)
P G McLean et al.
General pharmacology, 30(2), 227-231 (1998-03-21)
1. 5-Hydroxytryptamine (5-HT) has been shown to cause a consistent secretory effect in the rat small intestine only when administered luminally or by close intraarterial infusion. Intraluminal 5-HT-induced secretion is possibly mediated by 5-HT4 receptors. Therefore, it was decided to
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service