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N3529

Sigma-Aldrich

NAN-190 hydrobromide

Synonym(s):

1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C23H27N3O3 · HBr
CAS Number:
115338-32-4
Molecular Weight:
474.39
MDL number:
MFCD00078590
UNSPSC Code:
12352200
PubChem Substance ID:
24278108

SMILES string

Br.COc1ccccc1N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2

InChI

1S/C23H27N3O3.BrH/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28;/h2-5,8-11H,6-7,12-17H2,1H3;1H

InChI key

AXRUEPFPTQYHQD-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

Potent 5-HT1A serotonin receptor antagonist active in the nM range.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H335,H400

Precautionary Statements

P261 - P273 - P305 + P351 + P338

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R L Dennis et al.
Poultry science, 91(4), 817-822 (2012-03-09)
Aggression and cannibalism in laying hens can differ in intensity and degree due to many factors, including genetics. Previous behavioral analysis of 2 strains of White Leghorns, DeKalb XL (DXL) and HGPS (a group-selected line for high group productivity and
Jaime Pei Pei Foong et al.
Neuroreport, 20(3), 325-330 (2009-02-05)
Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of this study was to use intracellular recording and specific antagonists to identify roles of 5-HT1A and 5-HT7 receptors of submucosal
E J Kessler et al.
Neuroscience, 154(4), 1187-1194 (2008-06-10)
Health problems can arise from de-synchrony between the external environment and the endogenous circadian rhythm, yet the circadian system is not able to quickly adjust to large, abrupt changes in the external daily cycle. In this study, we investigated the
L Rydelek-Fitzgerald et al.
Brain research, 532(1-2), 191-196 (1990-11-05)
NAN-190 has been reported to be a 5-HT1A antagonist in drug discrimination studies. In order to determine if the effect of NAN-190 was directly due to competitive inhibition at 5-HT1A receptors, 5-HT1A-mediated inhibition of adenylyl cyclase in hippocampal membranes was
James Oluwagbamigbe Fajemiroye et al.
Journal of ethnopharmacology, 141(3), 872-877 (2012-04-05)
Medicinal applications of Pimenta pseudocaryophyllus infusion as a diuretic and aphrodisiac agent as well as tranquilizer in the form of tea for the treatment of emotional tension in Brazilian folk medicine has been in practice since time immemorial. Despite its
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