33211-M

Ethyl acetate

puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)

• Synonym(s): EtOAc
• Linear Formula: CH₃COOC₂H₅
• CAS Number: 141-78-6
• Molecular Weight: 88.11
• Beilstein: 506104
• EC Number: 205-500-4
• MDL number: MFCD00009171
• UNSPSC Code: 12352108
• PubChem Substance ID: 329754471
• NACRES: NA.21

Properties

• grade: ACS reagent; puriss. p.a.
• Quality Level: 200
• Agency: USP/NF; reag. ISO; reag. Ph. Eur.
• vapor density: 3 (20 °C, vs air)
• vapor pressure: 73 mmHg ( 20 °C)
• Assay: ≥99.5% (GC)
• form: liquid
• autoignition temp.: 801 °F
• expl. lim.: 2.2-11.5 %, 38 °F
• impurities: ≤0.001% non-volatile matter; ≤0.0045% free acid (as CH₃COOH); ≤0.05% water (Karl Fischer); ≤0.1% ethanol (GC); ≤0.1% isobutylalcohol; ≤0.1% methanol; ≤0.1% methyl acetate
• color: APHA: >10
• refractive index: n20/D 1.3710-1.3730; n20/D 1.3720 (lit.)
• bp: 76.5-77.5 °C (lit.)
• mp: −84 °C (lit.)
• density: 0.902 g/mL at 25 °C (lit.)
• cation traces: Al: ≤0.5 mg/kg; B: ≤0.02 mg/kg; Ba: ≤0.1 mg/kg; Bi: ≤0.1 mg/kg; Ca: ≤0.5 mg/kg; Cd: ≤0.05 mg/kg; Co: ≤0.02 mg/kg; Cr: ≤0.02 mg/kg; Cu: ≤0.02 mg/kg; Fe: ≤0.1 mg/kg; K: ≤0.5 mg/kg; Li: ≤0.1 mg/kg; Mg: ≤0.1 mg/kg; Mn: ≤0.02 mg/kg; Mo: ≤0.1 mg/kg; Na: ≤0.5 mg/kg; Ni: ≤0.02 mg/kg; Pb: ≤0.1 mg/kg; Sn: ≤0.1 mg/kg; Sr: ≤0.1 mg/kg; Zn: ≤0.1 mg/kg
• SMILES string: CCOC(C)=O
• suitability: passes test for reaction against H₂SO₄
• format: neat
• InChI: 1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
• InChI key: XEKOWRVHYACXOJ-UHFFFAOYSA-N

Description

General description

Ethyl Acetate (EtOAc) is an organic compound with a characteristic sweet smell. It is commonly used as a coating solvent for paints, lacquers, and varnishes. It is also used as an extraction solvent and reagent in many pharmaceutical industries.

Application

Ethyl acetate can be used as:     

• A reactant to synthesize cinnamyl acetate via lipase-catalyzed transesterification reaction between ethyl acetate and cinnamyl alcohol.      
• A reaction medium to synthesize solid electrolyte Li₃PS₄ by the reaction between Li₂S and P₂S₅.      
• A solvent in the synthesis of 6-O-acetyl glycosides via selective acetylation of carbohydrates in the presence of a catalytic amount of sulfuric acid. 6-O-acetyl glycoside derivatives are applicable as precursors for the synthesis of complex oligosaccharides.      
• A reactant to prepare geranyl acetate by transesterification of geraniol.      
• A green solvent in solid-phase peptide synthesis.

Features and Benefits

EtOAc is an environmentally safe solvent/reagent.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H319 - H336
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 26.6 °F - closed cup
• Flash Point(C): -3.00 °C - closed cup