D-044

Duloxetine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Duloxetine hydrochloride solution
• Empirical Formula (Hill Notation): C₁₈H₂₀ClNOS
• CAS Number: 136434-34-9
• Molecular Weight: 333.88
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: Cl.CNCCC(Oc1ccc2ccccc2c1)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-11-10-17(18-7-4-12-21-18)20-16-9-8-14-5-2-3-6-15(14)13-16;/h2-9,12-13,17,19H,10-11H2,1H3;1H
• InChI key: QZIJQNJKJMLFKV-UHFFFAOYSA-N

Description

General description

Duloxetine, marketed in the US under the trade name Cymbalta^®, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and to alleviate pain associated with diabetic neuropathy, fibromyalgia, and osteoarthritis. This Certified Spiking Solution^® is applicable for use in applications such as clinical toxicology, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.

Application

• Duloxetine HCl in Drug Release Studies: A study evaluated the application of bicarbonate buffer dissolution testing with gentle mechanistic stress to predict bioequivalence of enteric-coated pellet formulations including Duloxetine HCl, emphasizing its importance in CNS pharmacology and pharmaceutical quality control (Ikuta et al., 2024).


• Nanovesicle Formulation of Duloxetine: Research explored the formulation and optimization of ultra-elastic nanovesicles loaded with Duloxetine HCl, aimed at enhancing the antidepressant effect through intranasal and transdermal delivery. This approach provides insights into advanced drug delivery systems for CNS pharmacology and neurotransmitter research (Abd-Elal et al., 2023).


• Pharmacokinetics and Pharmacodynamics: An investigation into chitosan-grafted PLGA nanoparticles aimed to boost the pharmacokinetic and pharmacodynamic effect of Duloxetine HCl using Box-Benkhen Design, contributing to the understanding of its bioavailability and therapeutic efficacy in biochemical research on antidepressants (Salem et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Cymbalta is a registered trademark of Eli Lilly and Co.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup