923818
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide
Synonym(s):
Coumarin alkyne CoLDR probe
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C17H15NO4
Molecular Weight:
297.31
NACRES:
NA.22
reaction suitability
reagent type: chemical modification reagent
reaction type: click chemistry
Quality Level
functional group
(Alkyne)
storage temp.
2-8°C
SMILES string
O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1
Related Categories
Application
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service