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247480

Sigma-Aldrich

Domiphen bromide

97%

Synonym(s):

(Dodecyldimethyl-2-phenoxyethyl)ammonium bromide

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About This Item

Linear Formula:
CH3(CH2)11N(CH3)2(CH2CH2OC6H5)Br
CAS Number:
538-71-6
Molecular Weight:
414.46
EC Number:
208-702-0
MDL number:
MFCD00011769
UNSPSC Code:
12352112
PubChem Substance ID:
24854870
NACRES:
NA.22

Quality Level

100

Assay

97%

form

powder

mp

117-119 °C (lit.)

SMILES string

[Br-].CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1

InChI

1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1

InChI key

OJIYIVCMRYCWSE-UHFFFAOYSA-M

General description

Domiphen bromide (DMP) is a quaternary ammonium compound that belongs to the class of phenol ethers. It can be used as a cationic surfactant.

Application

  • Domiphen Bromide in Antimicrobial Applications: A clinical trial assessed the effectiveness of a mouthwash containing Domiphen Bromide among other quaternary ammonium compounds, showcasing its ability to significantly reduce gingivitis, supporting its use in dental health products (Rosa and Sturzenberger, 1976).
  • Toxicity and Safety Profile of Domiphen Bromide: A recent study explored the proarrhythmic effects induced by Domiphen Bromide in both in vitro and in vivo models, providing vital safety information crucial for its use in pharmaceutical applications (Long et al., 2021).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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F Scaglione et al.
International journal of clinical pharmacology research, 3(4), 261-264 (1983-01-01)
By means of a double blind, placebo controlled trial, we have studied 29 patients (14 M and 15 F) affected by different acute infectious oral diseases. Our results suggest that domifen bromide may be useful in treating infectious oral diseases
[Antiseptic activity of domiphen bromide on the yeast Candida in the mouth].
P Goumas et al.
Stomatologia, 41(5), 249-257 (1984-09-01)
Lorenzo H Chen et al.
Journal of pharmaceutical and biomedical analysis, 40(4), 964-970 (2005-10-26)
This report describes a rapid and accurate reversed phase HPLC method for the simultaneous quantitation of multiple surfactants in various bioprocess solution matrices including cell lysates. Separation and quantitation of a mixture of the cationic detergent domiphen bromide from the
F Scaglione et al.
International journal of clinical pharmacology research, 3(5), 357-361 (1983-01-01)
Thirty-one patients (21 M and 10 F), affected by acute infectious dental disease, were treated with domifen bromide (A) or placebo (Pl). It was found that A had a beneficial effect on the results of clinical controls and reduced the
Separation of fulvic acid from soil extracts based on ion-pair formation with a cationic surfactant
Fukushima M, et al.
Analytical Sciences, 22(2), 229-233 (2006)
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