PTPN6
protein tyrosine phosphatase, non-receptor type 6
Synonyms:
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Species:
Human PTPN6 (5777), Mouse Ptpn6 (15170), Rat Ptpn6 (116689), domestic guinea pig Ptpn6 (100723417), naked mole-rat Ptpn6 (101725029), Domestic Rabbit PTPN6 (100348648), cow PTPN6 (512312), sheep PTPN6 (101108643), Zebrafish ptpn6 (335573), chicken PTPN6 (427947) ...More
UniProtKB ID:
Gene ID:
- Human(5777) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
- Mouse(15170) protein tyrosine phosphatase, non-receptor type 6
- Rat(116689) protein tyrosine phosphatase, non-receptor type 6
- domestic guinea pig(100723417) protein tyrosine phosphatase, non-receptor type 6
- naked mole-rat(101725029) protein tyrosine phosphatase, non-receptor type 6
- Domestic Rabbit(100348648) protein tyrosine phosphatase, non-receptor type 6
- cow(512312) protein tyrosine phosphatase, non-receptor type 6
- sheep(101108643) protein tyrosine phosphatase, non-receptor type 6
- Zebrafish(335573) protein tyrosine phosphatase, non-receptor type 6
- chicken(427947) protein tyrosine phosphatase, non-receptor type 6
- Horse(100052882) protein tyrosine phosphatase, non-receptor type 6
- domestic cat(101087073) protein tyrosine phosphatase, non-receptor type 6
- dog(486717) protein tyrosine phosphatase, non-receptor type 6
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SHP-1/PTPN6 Antibody, clone 1D20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-PTPN6/SHP1 (Internal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-phospho-PTPN6 (pTyr536) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-PTPN6 (Ab-536) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-SHP-1 (pTyr536) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot