PTK2B
protein tyrosine kinase 2 beta
Synonyms:
CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
Species:
Human PTK2B (2185), Mouse Ptk2b (19229), Rat Ptk2b (50646), chicken PTK2B (421998), Horse PTK2B (100054547), domestic cat PTK2B (101091691), dog PTK2B (486102), domestic guinea pig Ptk2b (100734027), naked mole-rat Ptk2b (101714384), Domestic Rabbit PTK2B (100342358) ...More
UniProtKB ID:
Gene ID:
- Human(2185) Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19229) PTK2 protein tyrosine kinase 2 beta
- Rat(50646) protein tyrosine kinase 2 beta
- chicken(421998) PTK2B protein tyrosine kinase 2 beta
- Horse(100054547) PTK2B protein tyrosine kinase 2 beta
- domestic cat(101091691) PTK2B protein tyrosine kinase 2 beta
- dog(486102) PTK2B protein tyrosine kinase 2 beta
- domestic guinea pig(100734027) protein tyrosine kinase 2 beta
- naked mole-rat(101714384) protein tyrosine kinase 2 beta
- Domestic Rabbit(100342358) PTK2B protein tyrosine kinase 2 beta
- cow(541008) PTK2B protein tyrosine kinase 2 beta
- sheep(101106906) PTK2B protein tyrosine kinase 2 beta
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-PYK2 (pTyr881) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Pyk2/CAKβ Antibody, ,
Species Reactivity
human, rat
Application
immunocytochemistry
western blot
western blot
Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody, Upstate®, from rabbit,
Species Reactivity
human, rat
Application
immunocytochemistry
western blot
western blot
Anti-Phospho-PTK2B-Y402 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-PYK2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species
Pyk2 Protein, active, 10 µg, Active, N-Terminal His6-tagged, recombinant, full-length, human Pyk2. For use in Kinase Assays.,
Species
human