MMP12
matrix metallopeptidase 12 (macrophage elastase)
Synonyms:
HME, ME, MME, MMP-12
Species:
Human MMP12 (4321), Mouse Mmp12 (17381), Rat Mmp12 (117033), domestic cat MMP12 (101084472), cow MMP12 (526981), dog MMP12 (611789), naked mole-rat Mmp12 (101716268), Domestic Rabbit MMP12 (100009559), domestic guinea pig Mmp12 (100730930), sheep MMP12 (101119157)
UniProtKB ID:
Gene ID:
- Human(4321) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
- Mouse(17381) matrix metallopeptidase 12
- Rat(117033) matrix metallopeptidase 12
- domestic cat(101084472) matrix metallopeptidase 12 (macrophage elastase)
- cow(526981) matrix metallopeptidase 12 (macrophage elastase)
- dog(611789) matrix metallopeptidase 12 (macrophage elastase)
- naked mole-rat(101716268) matrix metallopeptidase 12 (macrophage elastase)
- Domestic Rabbit(100009559) matrix metallopeptidase 12 (macrophage elastase)
- domestic guinea pig(100730930) matrix metallopeptidase 12 (macrophage elastase)
- sheep(101119157) matrix metallopeptidase 12 (macrophage elastase)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
western blot
Anti-Matrix metalloproteinase-12 (MMP-12) antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM381, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-MMP-12 Antibody, NT (active), from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
western blot
Anti-MMP12 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human
Application
ELISA
western blot
western blot
Anti-MMP12 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
Matrix Metalloproteinase-12, Catalytic Domain human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
esiRNA
Product Number
Description
Species