- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper (S, P), BCR®, certified reference material, chips
Copper, IRMM®, certified reference material, 0.1 mm foil
Copper, IRMM®, certified reference material, 0.5 mm wire
Copper (O), BCR®, certified reference material, rod
Copper, wire reel, 1000m, diameter 0.1mm, annealed, 99.9%
Copper, wire reel, 200m, diameter 1.0mm, annealed, 99.9%
Copper, wire reel, 1m, diameter 0.5mm, as drawn, 99.999%
Copper, wire reel, 100m, diameter 0.5mm, annealed, 99.9%
Copper, wire reel, 0.5m, diameter 1.0mm, as drawn, 99.99+%
Copper, wire reel, 50m, diameter 0.025mm, as drawn, 99.99+%
Copper, wire reel, 25m, diameter 0.5mm, as drawn, 99.98+%
Copper, wire reel, 2000m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 200m, diameter 0.05mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.5mm, annealed, silver plated, 99.9%
Copper, wire reel, 1000m, diameter 0.25mm, annealed, 99.9%
Copper, wire reel, 20m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 100m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 2000m, diameter 0.04mm, annealed, 99.9%
Copper, wire reel, 0.5m, diameter 0.1mm, aluminum cladding, outside diameter 0.25mm, 99.9%
Copper, wire reel, 200m, diameter 0.075mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.5mm, as drawn, 99.999%
Copper, wire reel, 500m, diameter 0.04mm, hard, 99.9%
Copper, wire reel, 50m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 25m, diameter 1.0mm, annealed, 99.9%
Copper, wire reel, 2000m, diameter 0.25mm, annealed, 99.9%
Copper, wire reel, 50m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.01mm, hard, 99.99%
Copper, wire reel, 100m, diameter 0.02mm, annealed, 99.99%