Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report.

Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report.

Acta gastro-enterologica Belgica (2012-08-09)

Arnaud Devresse, Philippe Maldague, Bruno Coulier, Frédéric Pierard, Isabelle Gielen

ABSTRACT

We present the case of a 26-year-old man with schizoid personality disorder who suffered from a very focal and transparietal necrosis of the sigmoid after an overdose of atypical neuroleptics. This is a singular, rather unknown and potentially lethal side effect of these drugs. The physiopathology of this complication is multifactorial.

MATERIALS

Product Number

Brand

Product Description

T6154

Sigma-Aldrich

Trazodone hydrochloride, ≥99% (HPLC), powder

T-030

Supelco

Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®