Skip to Content
Merck
HomeProductsAnalytical ChemistryAnalytical Sample PreparationSolid Phase Extraction & QuEChERS

Solid Phase Extraction & QuEChERS

Solid Phase Microextraction

Solid Phase Extraction (SPE) is a technique designed for rapid and selective sample preparation and purification, prior to chromatographic analysis. The multitude of available phase chemistries can be packed into an array of hardware formats such as individual cartridges, 96-well plates, and QuEChERS tubes (dispersive SPE), which can be processed using a vacuum manifold and dedicated accessories.

Request a Sample

Related Product Resources

Brochure: Solid Phase Extraction Products
Brochure: Supel™ QuE QuEChERS
Brochure: HybridSPE® Phospholipid Removal Technology for Biological Matrices
Application Note: Supel™ DPX HLB tips and Hamilton® - Extraction of opioid drugs from urine
Application Note: Empore™ C18 SPE Disk app note
Application Note: Simplified LC-MS/MS Method for Glyphosate, AMPA and Glyfosinate in oat-based cereals

Selection Guide: Supel™ QuE for QuEChERS
Flyer: DPX HybridSPE® Tips
Flyer: Supel™ Swift HLB SPE Cartridges
Application Note: LC-MS Analysis of PFAS Compounds in EPA 533 after Supelclean™ ENVI-WAX™ SPE Cleanup

Prepacked Supelco® Discovery® DSC 18 SPE cartridges

SPE Packed Cartridges

We offer a diverse range of SPE-phase chemistries and cartridges ideal for many applications including pharmaceutical, clinical, food and beverage, environmental, petrochemical, and agriculture. The phase chemistry selection allows users to screen for the retention and selectivity required to achieve sample preparation objectives.

Discovery® DSC-18 Supelco® 96 well plate assembly for high throughput pharmaceutical screening and analysis

SPE Well Plates

Our SPE well plates allow users to process up to 96 samples simultaneously for increased reproducibility and throughput, while maintaining excellent recoveries and increased sensitivity. 96-well plates offer compatibility with multi-channel pipettors and automation, and are available with silica-based and polymeric sorbents.

Online SPE cartridge with the holder

Online SPE Cartridges

Supel™ Genie Online SPE cartridges offer a sample preparation solution for a seamless workflow from start to finish performed entirely “online” using the LC instrument. Online SPE offers the advantage of eliminating the risk of human error and reduces labor costs by automation of sample preparation.

Centrifuge tube containing pre-determined amount of Supel™ QuE Verde sorbent for dSPE in challenging green matrices.

QuEChERS

The “QuEChERS” (Dispersive SPE, dSPE) method has emerged as a popular sample preparation technique in the area of multi-residue pesticide analysis for food and agricultural products. The QuEChERS technique offers the advantage of higher recoveries, accurate results and high sample throughput.

HybridSPE® DPX tips provides an INTip solution for complete sample preparation.

Dispersive Pipette Extraction (DPX®) Tips

DPX® tips provide an INTip solution for complete sample preparation that can be easily automated to achieve extraction in seconds. HybridSPE® sorbent material is loosely contained within a tip, for selective retention and removal of endogenous phospholipid interferences from biological matrices for LC-MS or LC-MS/MS analysis.

Supelclean™ ENVI™-8 DSK SPE membrane for faster processing of larger sample volumes

Discs

SPE disks are porous glass fiber membranes embedded with modified silica particles that provide fast flow rates for processing large sample volumes. We offer SPE disks that accommodate rapid organic contaminant extraction, making them ideal for the EPA 500 series, including 525.1 and 508.1.

Solid Phase Extraction Accessories

To facilitate sample preparation requirements, we offer a range of accessories including SPE tube components, elution racks, drying attachments, single SPE tube processors, vacuum pump trap kits, disk holders, and vacuum manifolds.

Related Product Categories
HPLC Columns
Achieve precise separations with our extensive HPLC column collection. Enhance retention, resolution, and selectivity. Order today.
Solvents
Your Solvent Source: Find the right fit with Supelco®, SigmaAldrich®, & SAFC® brands, covering analytical, lab, & biopharmaceutical uses. Order online.
Chromatography Standards
Certified Reference Materials & reference standards for chromatography-based testing applications including forensic and clinical toxicology analysis, diagnostic testing, therapeutic drug monitoring, cannabis testing, environmental analysis, pharmaceutical research, and food & beverage testing.
Certified Reference Materials
Browse our Certified Reference Materials (CRMs) for applications in forensic and clinical toxicology analysis, diagnostic testing, therapeutic drug monitoring, cannabis testing, environmental analysis, pharmaceutical research, and food & beverage testing.
Related Applications
Mass Spectrometry
Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.
Gas Chromatography (GC)
Gas chromatography is a common analytic technique used to separate and analyze volatile compounds in the gas phase. GC is applied in many industries for quality control, and to identify and/or quantify compounds in a mixture.
Solid Phase Extraction (SPE)
Solid phase extraction (SPE) is a technique used for rapid, selective sample preparation and purification prior to chromatographic analysis (e.g. HPLC, GC, TLC). SPE is used to exchange sample matrices, concentrate analytes, and remove interferences and contaminants to improve data and protect the analytical column.
QuEChERS Sample Preparation Method
QuEChERS is a ‘Quick, Easy, Cheap, Effective, Rugged and Safe’ sample cleanup method used to prepare food and agricultural samples for pesticides analysis. QuEChERS is based on the Solid Phase Extraction (SPE) technique of sample preparation.
Sample Preparation by Filtration
Filtration separates substances based on physical or chemical properties. Lab samples are routinely filtered before analysis to reduce sample complexity and increase analyte purity. This allows scientists to generate higher quality analytical results.
Sample Purification
A range of purification methods may be used to prepare a sample prior to downstream analysis. Purification reduces sample complexity, removes interferences, and concentrates an analyte before analysis.
Large Molecule HPLC
High performance liquid chromatography (HPLC) can be used to separate and identify different large biomolecules such as protein and peptides in a sample. It is based on the pumping of a sample with a solvent (mobile phase) through a column packed with sorbent material (stationary phase) at a high pressure.
Small Molecule HPLC
Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).
Related Services
Custom SPE Tubes and 96-Well Plates
Solid phase extraction (SPE) is a technique designed for rapid, selective sample preparation and purification prior to chromatographic analysis. To meet your analytical needs, we offer custom SPE Tubes, 96-well plates, and other formats upon request.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?