SML0743

EUK-134

≥95% (HPLC)

• Synonym(s): (SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese, 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex, Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2′,O1,O1′]-manganese, EUK 134
• Empirical Formula (Hill Notation): C₁₈H₁₈ClMnN₂O₄
• CAS Number: 81065-76-1
• Molecular Weight: 416.74
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: , faint to very dark brown
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• InChI: 1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3
• InChI key: YUZJJFWCXJDFOQ-UHFFFAOYSA-K

Description

Application

EUK-134 has been used as an antioxidant.

EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs).

Biochem/physiol Actions

EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

Other Notes

air sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable