SAB5200104
Anti-SLC12A3 antibody produced in rabbit
1 mg/mL, affinity isolated antibody
Synonym(s):
Anti-NCC, Anti-Slc12a3
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All Photos(2)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 160 kDa
species reactivity
human, rat, mouse
concentration
1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC12A3(6559)
rat ... Slc12a3(54300)
General description
Solute carrier family 12 member 3 (SLC12A3) is also known as thiazide-sensitive Na+-Cl- cotransporter (NCCT). It is expressed in the apical cells of the distal convoluted tubule. The gene encoding this 1021 amino acid protein is localized on human chromosome 16q13. The gene ID for the protein is 6559.
Specificity
Detects ~160 kDa.
Immunogen
AA74-95 (rat), 76-97 (hum)
Biochem/physiol Actions
Solute carrier family 12 member 3 (SLC12A3) is one of the major components of the sodium chloride reabsorption pathway. It controls the Cl- concentration and is also involved in the transepithelial ion absorption and secretion. Mutations in the gene encoding SLC12A3 have been associated with Gitelman syndrome.
This Na-Cl cotransporter is associated with maintaining blood pressure.
Features and Benefits
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Physical form
PBS, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population
An C, et al.
Lipids in Health and Disease, 17(1), 83-83 (2018)
Jiewei Luo et al.
Endocrine journal, 62(1), 29-36 (2014-10-03)
Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study
Linghong Wang et al.
Acta biochimica et biophysica Sinica, 47(5), 325-334 (2015-04-07)
The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is responsible for the major sodium chloride reabsorption pathway, which is located in the apical membrane of the epithelial cells of the distal convoluted tubule. TSC is involved in several physiological activities including transepithelial ion
Koichiro Susa et al.
Human molecular genetics, 23(19), 5052-5060 (2014-05-14)
Pseudohypoaldosteronism type II (PHAII) is a hereditary disease characterized by salt-sensitive hypertension, hyperkalemia and metabolic acidosis, and genes encoding with-no-lysine kinase 1 (WNK1) and WNK4 kinases are known to be responsible. Recently, Kelch-like 3 (KLHL3) and Cullin3, components of KLHL3-Cullin3
P Gailly et al.
Pflugers Archiv : European journal of physiology, 466(11), 2035-2047 (2014-01-28)
Luminal nucleotide stimulation is known to reduce Na(+) transport in the distal nephron. Previous studies suggest that this mechanism may involve the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC), which plays an essential role in NaCl reabsorption in the cells lining the distal
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