Skip to Content
Merck
All Photos(1)

Key Documents

MABF384

Sigma-Aldrich

Anti-CD127 (IL-7Ra) Antibody (mouse), clone A7R34

clone A7R34, 0.5 mg/mL, from rat

Synonym(s):

Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

A7R34, monoclonal

species reactivity

mouse

concentration

0.5 mg/mL

technique(s)

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2aκ

UniProt accession no.

Q60943

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Il7R(16197)

General description

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

Application

This Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), clone A7R34, Cat. No. MABF384 is validated for use in IP, IHC, Immunofluorescence and Flow Cytometry for the detection of CD127 (IL-7Ra).

Physical form

Format: Purified

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Gabrielle L Goldberg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 6014-6024 (2010-05-21)
Cytotoxic antineoplastic therapy is used to treat malignant disease but results in long-term immunosuppression in postpubertal and adult individuals, leading to increased incidence and severity of opportunistic infections. We have previously shown that sex steroid ablation (SSA) reverses immunodeficiencies associated

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service