PSEN1
presenilin 1
Synonyms:
AD3, FAD, PS-1, PS1, S182
Species:
Human PSEN1 (5663), Mouse Psen1 (19164), Rat Psen1 (29192), cow PSEN1 (282705), sheep PSEN1 (101102488), naked mole-rat Psen1 (101716186), Domestic Rabbit PSEN1 (100008886), domestic guinea pig Psen1 (100728153), Zebrafish psen1 (30221), domestic cat PSEN1 (101087239) ...More
UniProtKB ID:
Gene ID:
- Human(5663) Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- Mouse(19164) presenilin 1
- Rat(29192) presenilin 1
- cow(282705) presenilin 1
- sheep(101102488) presenilin 1
- naked mole-rat(101716186) presenilin 1
- Domestic Rabbit(100008886) presenilin 1
- domestic guinea pig(100728153) presenilin 1
- Zebrafish(30221) presenilin 1
- domestic cat(101087239) presenilin 1
- dog(403408) presenilin 1
- chicken(373977) presenilin 1
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Presenilin-1 Antibody, NT, clone hPS1-NT, culture supernatant, clone hPS1-NT, Chemicon®,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Presenilin 1 Antibody, Chemicon®, from chicken,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, CT, serum, Chemicon®,
Species Reactivity
hamster, human, monkey, mouse
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Presenilin 1 Antibody, clone 3W4V8, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-Presenilin 1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot