APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Synonyms:
APE2, APEXL2, XTH2
Species:
Human APEX2 (27301), Mouse Apex2 (77622), Rat Apex2 (317628), domestic guinea pig Apex2 (100722391), naked mole-rat Apex2 (101701150), sheep APEX2 (101116123), Zebrafish apex2 (393115), dog APEX2 (491499), cow APEX2 (511790), domestic cat APEX2 (101095317)
UniProtKB ID:
Gene ID:
- Human(27301) Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
- Mouse(77622) apurinic/apyrimidinic endonuclease 2
- Rat(317628) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- domestic guinea pig(100722391) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- naked mole-rat(101701150) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- sheep(101116123) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- Zebrafish(393115) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- dog(491499) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- cow(511790) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- domestic cat(101095317) APEX nuclease (apurinic/apyrimidinic endonuclease) 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-APEX2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-APEX2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species